High‐Load Core@Shell Nanocarriers with Irinotecan and 5‐Fluorouracil for Combination Chemotherapy in Colorectal Cancer
Combination Chemotherapy Core@shell nanocarriers (scheme, top left) with a drug cocktail of irinotecan (ITC, core) and 5-fluoruridine (5FU, shell) and a high drug payload demonstrate high cytotoxic efficacy in rectal cancer patient-derived organoids (PDO cells: green; nuclei: blue). The cover shows the nanocarriers (red) in the cells at the periphery or in the lumen of the PDOs. More in article number 2400196, Frauke Alves, Claus Feldmann, and co-workers.
Authors
- Claus Feldmann (ORCID: https://orcid.org/0000-0003-2426-9461)
- Dolma Choezom (ORCID: https://orcid.org/0000-0003-4163-1725)
- Lena‐Christin Conradi (ORCID: https://orcid.org/0000-0002-9488-1018)
- Frauke Alves (ORCID: https://orcid.org/0000-0002-6258-5409)
- Fernanda Ramos‐Gomes (ORCID: https://orcid.org/0000-0001-6560-3476)
- Tiago De Oliveira (ORCID: https://orcid.org/0000-0002-2502-7897)
- Silke Notter
- Titus Griebel
- Wiebke Möbius (ORCID: https://orcid.org/0000-0002-2902-7165)
Institutions
- Karlsruhe Institute of Technology (DE)
- Max Planck Institute for Multidisciplinary Sciences (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Small Science
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1002/smsc.202470047
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00