Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization
These results indicate that the endogenous CCL2-CCR2 and CGRP signaling pathways are not involved in sumatriptan-induced behavioral sensitization, suggesting that distinct molecular mechanisms underlie chronic migraine and MOH. On the other hand, peripheral CCL2-CCR2 signaling is required for LD-IL-2 to reverse chronic headache-related sensitization.
Authors
- Richard S. Hotchkiss (ORCID: https://orcid.org/0000-0002-5470-3655)
- Yuqing Cao (ORCID: https://orcid.org/0000-0003-2850-5492)
- Jacqueline Unsinger
- Zhaohua Guo (ORCID: https://orcid.org/0000-0001-9586-5688)
- Jintao Zhang (ORCID: https://orcid.org/0000-0003-2300-4998)
- Xuemei Liu (ORCID: https://orcid.org/0000-0002-2882-5798)
- Li Feng (ORCID: https://orcid.org/0000-0001-7217-9220)
- Roli Simoes
- Sun Ryu
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s10194-024-01900-5
- Citations
- 9
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 3.47
Funders
- National Institutes of Health