Photoredox-Catalyzed Multicomponent α-Sulfonylation of Terminal Alkynes
A generality-oriented and adaptive α-sulfonylation of alkynes via photoinduced multicomponent radical cross-coupling of terminal alkynes with sulfinates and a variety of alcohols, thiophenols, or selenophenols has been explored. This protocol features mild conditions, good functional group tolerability, broad substrate scope, excellent chemo-, site-, and stereoselectivity, and applicability to late-stage functionalization. It provides a modular platform for the synthesis of value-added structurally diverse α-sulfonyl-containing multisubstituted alkenes from simple precursors.
Authors
- Xin Zhuang
- Qianfa Jia (ORCID: https://orcid.org/0000-0001-6005-0614)
- Mingyue Zheng (ORCID: https://orcid.org/0000-0002-3323-3092)
- Qiao Ren (ORCID: https://orcid.org/0000-0002-1933-0160)
- Jicheng Wu (ORCID: https://orcid.org/0000-0002-6580-3416)
Institutions
- Southwest University (CN)
- Chongqing University (CN)
- Yangtze Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1021/acs.orglett.4c03828
- Citations
- 4
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Venture and Innovation Support Program for Chongqing Overseas Returnees
- Fundamental Research Funds for the Central Universities