Identification of <i>Veillonella parvula</i> and <i>Streptococcus gordonii</i> adhesins mediating co-aggregation and its impact on physiology and mixed biofilm structure

Our research explores the mechanisms of bacterial adhesion within the dental plaque, focusing on <i>Veillonella parvula</i>, a key player in the oral microbiome. Dependent on lactate from streptococci, <i>V. parvula</i> plays a crucial bridging role in the formation of dental biofilms by co-aggregating with other bacteria. Despite its importance, the understanding of the underlying mechanisms of co-aggregation remains limited. Our study shows that <i>V. parvula</i> uses different trimeric autotransporters to adhere to oral Streptococci and Actinomyces. We additionally identify a novel adhesin from <i>S. gordonii</i>, VisA (SGO_2004) facilitating this interaction. We found that although co-aggregation does not affect cell-cell communication, it is critical for biofilm structure and species distribution. This research opens up new avenues for exploring microbial interactions in dental health and diseases.

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Publication Details

Journal
mBio
Published
2024-11-11
DOI
https://doi.org/10.1128/mbio.02171-24
Citations
15
Primary Topic
Oral microbiology and periodontitis research
Type
article
Field-Weighted Citation Impact
6.01

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article

Identification of Veillonella parvula and Streptococcus gordonii adhesins mediating co-aggregation and its impact on physiology and mixed biofilm structure

Romain Briandet, Julien Deschamps, Yakov Vitrenko, Rania Ouazahrou et al.
15 citations
mBio
Oral microbiology and periodontitis research
6.01
article

Identification of Veillonella parvula and Streptococcus gordonii adhesins mediating co-aggregation and its impact on physiology and mixed biofilm structure

Romain Briandet, Julien Deschamps, Yakov Vitrenko, Rania Ouazahrou, Simonetta Gribaldo, Camille Martin‐Gallausiaux, Christophe Beloin, Jean‐Marc Ghigo, Nathalie Béchon, Susan Chamorro-Rodriguez, Louis Dorison, Romain Villa
article en
15 citations

Abstract

Our research explores the mechanisms of bacterial adhesion within the dental plaque, focusing on <i>Veillonella parvula</i>, a key player in the oral microbiome. Dependent on lactate from streptococci, <i>V. parvula</i> plays a crucial bridging role in the formation of dental biofilms by co-aggregating with other bacteria. Despite its importance, the understanding of the underlying mechanisms of co-aggregation remains limited. Our study shows that <i>V. parvula</i> uses different trimeric autotransporters to adhere to oral Streptococci and Actinomyces. We additionally identify a novel adhesin from <i>S. gordonii</i>, VisA (SGO_2004) facilitating this interaction. We found that although co-aggregation does not affect cell-cell communication, it is critical for biofilm structure and species distribution. This research opens up new avenues for exploring microbial interactions in dental health and diseases.

mBioVol. 15(12)
Centre National de la Recherche Scientifique (FR), Institut Pasteur (FR), Université Paris Cité (FR), AgroParisTech (FR), Université Paris-Saclay (FR), Microbiologie de l’alimentation au service de la santé (FR), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Agence Nationale de la Recherche
Life in Land
Openalex Percentile: Top 3%
Oral microbiology and periodontitis research
6.01
DOIOpen Access PDFOpenAlex
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