A Phase 2 Sensitivity and Selectivity Study of High-Dose 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent Glioblastoma
High-dose oral 5-aminolevulinic/protoporphyrin fluorescence is a safe and effective aid to the intraoperative detection of high-grade gliomas with high sensitivity and specificity. False-negative observations with a high dose do not seem to be less than that with a low/standard dose. The rate of FP observations with both groups remains very low.
Authors
- Amber Fifer (ORCID: https://orcid.org/0000-0003-1586-1906)
- Breck A. Jones
- Brian E. Moore (ORCID: https://orcid.org/0000-0001-7914-1794)
- Leslie Acakpo‐Satchivi
- Barbara C. Lokaitis
- Ava Hoeft
- Jeffrey W. Cozzens (ORCID: https://orcid.org/0000-0003-4576-6942)
- Kristin R. Delfino (ORCID: https://orcid.org/0000-0003-0075-1472)
- José A. Espinosa (ORCID: https://orcid.org/0000-0001-9674-8125)
- Devin V. Amin
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Southern Illinois University School of Medicine (US)
- University Medical Center (US)
- Center for Clinical Research (United States) (US)
- Springfield Clinic (US)
Publication Details
- Journal
- Operative Neurosurgery
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1227/ons.0000000000001417
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.88