Targeting SPP1-orchestrated neutrophil extracellular traps-dominant pre-metastatic niche reduced HCC lung metastasis
Our study illustrates that HCC-lung host cell-neutrophil interactions play important roles in PMN formation and SPP1-induced HCC lung metastasis. Early intervention in SPP1-orchestrated PMN via CXCR2 inhibitor and DNase I is a potential therapeutic strategy to combat HCC lung metastasis.
Authors
- Xiaotian Shen (ORCID: https://orcid.org/0000-0001-5552-7473)
- Ran Wei (ORCID: https://orcid.org/0000-0002-5121-3650)
- Junjie Pan (ORCID: https://orcid.org/0000-0002-7570-6927)
- Jianfeng Xu (ORCID: https://orcid.org/0000-0002-1343-8752)
- Sun‐Zhe Xie
- Haoting Sun (ORCID: https://orcid.org/0000-0003-1386-5612)
- Hao Xu (ORCID: https://orcid.org/0000-0002-5665-0139)
- Lun–Xiu Qin (ORCID: https://orcid.org/0000-0003-4805-8239)
- Wenwei Zhu (ORCID: https://orcid.org/0000-0002-4112-9156)
- Lu Lu (ORCID: https://orcid.org/0000-0002-2255-0391)
- Chen Zhang (ORCID: https://orcid.org/0000-0002-6570-5947)
- Hao Wang (ORCID: https://orcid.org/0000-0001-5173-8089)
- Ming Lü (ORCID: https://orcid.org/0000-0002-3749-5321)
- Luyu Yang
- Xin Zheng
- Shizhe Yu (ORCID: https://orcid.org/0009-0004-5652-7642)
- Yufeng Su
Institutions
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s40164-024-00571-x
- Citations
- 20
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.81
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Fudan University