Survivin Promotes Stem Cell Competence for Skin Cancer Initiation
This study identifies Survivin as a key regulator of the different ability of SCs and Ps to initiate skin cancer. Survivin expression in oncogene-targeted SCs is essential for their survival and self-renewal and to prevent their differentiation and apoptosis, allowing SCs and not Ps to initiate skin cancer.
Authors
- Silvia Schenone (ORCID: https://orcid.org/0000-0002-3286-786X)
- Adriana Sánchez‐Danés (ORCID: https://orcid.org/0000-0001-7895-9973)
- Yura Song (ORCID: https://orcid.org/0000-0002-1173-9172)
- Sara Canato (ORCID: https://orcid.org/0000-0002-1102-0192)
- Mélanie Liagre (ORCID: https://orcid.org/0009-0005-6814-5083)
- Sofia Carvalho-Marques (ORCID: https://orcid.org/0000-0002-8983-0531)
- Raquel Maia Soares (ORCID: https://orcid.org/0000-0003-1299-4236)
- Pauline Vieugué
- Edward M. Conway (ORCID: https://orcid.org/0000-0003-0081-0305)
- Rahul M. Sarate (ORCID: https://orcid.org/0000-0001-8033-370X)
- Erik Cardoso (ORCID: https://orcid.org/0000-0001-8302-2341)
- Cédric Blanpain (ORCID: https://orcid.org/0000-0002-4028-4322)
- Giancarlo Grossi (ORCID: https://orcid.org/0000-0001-8586-004X)
- Christine Dubois
- Sara Monteiro-Ferreira (ORCID: https://orcid.org/0000-0003-0748-141X)
Institutions
- Champalimaud Foundation (PT)
- Université Libre de Bruxelles (BE)
- University of British Columbia (CA)
- University of Genoa (IT)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0263
- Citations
- 5
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Fonds Erasme
- Fonds De La Recherche Scientifique - FNRS
- Stichting Tegen Kanker
- European Research Council
- Fundação para a Ciência e a Tecnologia
- HORIZON EUROPE Widening Participation and Strengthening the European Research Area