Metabolism and Clinical Significance of Triglycerides

Triglycerides, the principal form of fat storage in animals and humans, are essential in view of their roles in energy metabolism and regulation. Indeed, they have been ascribed very vital functional significance in a plethora of physiological processes, which extends to energy storage, metabolic signaling, and disease pathology. Biochemistry and metabolism of triglycerides is a multivaried area of science that includes different mechanisms that control synthesis, storage, and utilization in organisms. For many years, the issue of triglycerides and their relationship to cardiovascular disease (CVD) has been one of the central themes of research. Elevated triglyceride levels frequently associate with an elevated cardiovascular risk, but the situation is complex and multifaceted at all. It has now been reported that triglycerides could act not only as a biomarker regarding cardiovascular risk but also play an actual part in the fostering of cardiovascular disorders. The present literature review juxtaposes key findings on triglyceride metabolism, thereby underlining implications for health and disease, with the end to identify works currently associating triglyceride implications in cardiovascular health, and further to explore determinants of triglyceride levels gap that warrant further investigation.