Olaparib enhancing radiosensitization and anti-metastatic effect of oral cancer by targeting IL-17A signal
This study has highlighted that Olaparib displays radiosensitizing and antimetastatic effects by inhibiting the IL-17 A-dependent signal. Remarkably, Olaparib could provide a remarkable anticancer efficacy to improve treatment response in OSCC patients with recurrent/metastatic disease after RT.
Authors
- Liang‐Cheng Chen (ORCID: https://orcid.org/0000-0002-0657-5636)
- Chen-Lin Chi
- Wen‐Yen Chiou (ORCID: https://orcid.org/0000-0002-5541-6834)
- Shih‐Kai Hung (ORCID: https://orcid.org/0000-0002-4945-528X)
- Hsuan-Ju Yang (ORCID: https://orcid.org/0000-0001-7819-0535)
- Chia-Hui Chew
- Shu‐Fen Wu
- Chih‐Chia Yu
- Michael W.Y. Chan (ORCID: https://orcid.org/0000-0003-0314-2437)
- Hon‐Yi Lin
- Ru‐Inn Lin
- Feng-Chun Hsu
- Moon-Sing Lee
Institutions
- National Chung Cheng University (TW)
- Kaohsiung Medical University (TW)
- Tzu Chi University (TW)
- Taipei Tzu Chi Hospital (TW)
- Buddhist Tzu Chi Medical Foundation (US)
- Chiayi Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s12935-024-03547-3
- Citations
- 4
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.13