Several meta-analyses missing from an umbrella review of <i>n</i>-3 fatty acids on depression symptoms: comments concerning Lu <i>et al</i>.

Several meta-analyses missing from an umbrella review of n-3 fatty acids on depression symptoms: comments concerning Lu et al.I have read with interest the study by Lu et al. (1) , who summarised the available evidence regarding the effects of n-3 PUFA on symptoms of depression.Unfortunately, the study likely failed to provide a truly comprehensive perspective on the topic and may have presented unreliable conclusions.According to the authors, the last search was performed in June 2021, but at least one eligible meta-analysis (published in March 2021) is missing (2) .Considering that Lu et al. were interested in any population of adults, according to their Population, Intervention, Comparison and Outcomes (PICO) criteria, the study by O'Deane et al. (2021) (2) provided relevant data and should have been included.This high-quality review presents a Grading of Recommendations Assessment, Development and Evaluations (GRADE) assessment based on