NBS-Mediated C(sp2)-H Bond Chlorination of Enaminones: Using DCE as Chlorine Source
Commercial DCE is excavated as both a "Cl" source and a solvent for the vinyl C(sp<sup>2</sup>)-H chlorination. The strategy involves a metal-free NBS-mediated C(sp<sup>2</sup>)-H chlorination of enaminones, and affords diverse, functionalized <i>α</i>-chlorinated enaminones with a <i>Z</i>-configuration. This mild and effective approach not only advances the vinyl C(sp<sup>2</sup>)-H chlorination, employing DCE as the "Cl" source, but also provides a new strategy for accessing chlorinated enaminone derivatives.
Authors
- Zhilai Zhang (ORCID: https://orcid.org/0009-0007-4070-3674)
- Fuchao Yu (ORCID: https://orcid.org/0000-0001-5557-3824)
- Siyu Song (ORCID: https://orcid.org/0000-0001-9160-3111)
- Yongchao Wang (ORCID: https://orcid.org/0000-0003-2248-6630)
- Huimin Hu (ORCID: https://orcid.org/0000-0001-5712-3624)
- Menglin Peng
- Yuanzheng Wei
- Yunhua Xie
Institutions
- Kunming University of Science and Technology (CN)
- Yunnan Normal University (CN)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-11-10
- DOI
- https://doi.org/10.3390/ijms252212073
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.25