NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA
NAT10 mediates ac4C modification of Srebf1 and Scap mRNA, thereby affecting lipogenesis in the liver. This study provided a new target for the treatment of MASLD.
Authors
- Md. Asaduzzaman Khan (ORCID: https://orcid.org/0000-0001-7851-0500)
- Xuan Yi (ORCID: https://orcid.org/0000-0002-6055-8052)
- Zhouqi Wang (ORCID: https://orcid.org/0009-0006-1298-6913)
- Xiaoying Sun (ORCID: https://orcid.org/0009-0007-5560-2446)
- Kexin Chen (ORCID: https://orcid.org/0000-0003-4248-7681)
- Peng Lin (ORCID: https://orcid.org/0000-0003-3760-5575)
- Xinxing Wan (ORCID: https://orcid.org/0000-0002-6617-0331)
Institutions
- Central South University (CN)
- North South University (BD)
- The First Hospital of Changsha (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s12944-024-02360-1
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.10