Copper oxide nanoparticles exacerbate chronic obstructive pulmonary disease by activating the TXNIP-NLRP3 signaling pathway
We elucidated the exacerbating effect of CuONPs exposure on the respiratory tract with underlying COPD, as well as related signaling transduction via TXNIP regulation. CuONPs exposure significantly increased inflammatory responses in the respiratory tract, which was correlated with elevated TXNIP-NLRP3 signaling.
Authors
- Woong‐Il Kim (ORCID: https://orcid.org/0000-0002-3308-0313)
- Je‐Oh Lim (ORCID: https://orcid.org/0000-0002-0648-8348)
- Sung-Hwan Kim (ORCID: https://orcid.org/0000-0001-6876-737X)
- Sin-Hyang Park
- Jong-Choon Kim
- So‐Won Pak
- Dong‐Il Kim (ORCID: https://orcid.org/0000-0002-5313-9554)
- Se‐Jin Lee (ORCID: https://orcid.org/0000-0003-1523-0389)
- In-Sik Shin
Institutions
- Chonnam National University (KR)
- Korea Institute of Oriental Medicine (KR)
- Korea Institute of Toxicology (KR)
- National University College (PR)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s12989-024-00608-3
- Citations
- 13
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Research Foundation
- Chonnam National University
- Korea Institute of Toxicology
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea