Dextran-Graft-Polyacrylamide/Zinc Oxide Nanoparticles Inhibit of Cancer Cells in vitro and in vivo
D-PAA/ZnO NPs nanosystems were internalized by prostate, breast cancer cells and non-malignant cells via endocytosis after short time, but cytotoxicity against non-cancer cells were significantly lower in vitro and in vivo. D-PAA/ZnO NPs nanocomplex efficiently promoted cell death of tumor cells without showing cytotoxicity against non-malignant cells making it a promising anti-cancer agent.
Authors
- Petro Virych (ORCID: https://orcid.org/0000-0001-6201-3892)
- Volodymyr O. Doroschuk (ORCID: https://orcid.org/0000-0001-6703-1926)
- Volodymyr Prokopіuk (ORCID: https://orcid.org/0000-0003-4379-4130)
- Valentyna Kurovska (ORCID: https://orcid.org/0000-0002-7295-5549)
- Pavlo Virych (ORCID: https://orcid.org/0000-0002-1463-1992)
- Mykola V. Ischenko (ORCID: https://orcid.org/0000-0002-0851-1679)
- Anatolii Onishchenko (ORCID: https://orcid.org/0000-0002-2122-2361)
- Nataliya Kutsevol (ORCID: https://orcid.org/0000-0002-1468-4111)
- Anton Tkachenko (ORCID: https://orcid.org/0000-0002-1029-1636)
Institutions
- National Academy of Sciences of Ukraine (UA)
- Taras Shevchenko National University of Kyiv (UA)
- R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (UA)
- Institute for Problems of Cryobiology and Cryomedicine (UA)
- Kharkiv National Medical University (UA)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/ijn.s485106
- Citations
- 4
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.24