Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis
Coordinate analysis of protein expression in DM and JDM patient sera by a multiplex immunoassay validated previous gene expression studies and identified novel dysregulated proteins, altered signaling pathways, and candidate disease activity biomarkers. These findings may further inform the assessment of DM and JDM patients and aid in the identification of potential therapeutic targets.
Authors
- Payam Noroozi Farhadi (ORCID: https://orcid.org/0000-0003-2419-050X)
- Anna Clare Sparling (ORCID: https://orcid.org/0009-0001-1807-0221)
- Kamelia Zerrouki
- Jian‐Liang Li
- Lisa G. Rider (ORCID: https://orcid.org/0000-0002-6912-2458)
- Frederick W. Miller (ORCID: https://orcid.org/0000-0003-2831-9593)
- Kerry A. Casey (ORCID: https://orcid.org/0000-0001-7194-8585)
- James M. Ward (ORCID: https://orcid.org/0000-0002-9510-2848)
- Adam I. Schiffenbauer (ORCID: https://orcid.org/0000-0001-9964-9966)
- Michael A. Smith (ORCID: https://orcid.org/0009-0005-3694-3187)
- Kakali Sarkar (ORCID: https://orcid.org/0000-0001-6391-5660)
- Saifur Rahman
Institutions
- National Institutes of Health (US)
- National Institute of Environmental Health Sciences (US)
- AstraZeneca (United States) (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s13075-024-03421-7
- Citations
- 2
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- U.S. Department of Health and Human Services
- AstraZeneca
- National Institutes of Health
- National Institute of Environmental Health Sciences