Construction and Validation of a Novel T/NK-Cell Prognostic Signature for Pancreatic Cancer Based on Single-Cell RNA Sequencing
A novel prognostic T/NK-cell signature for pancreatic cancer was constructed based on scRNA-seq data and externally validated. The involved key genes may play a role in multiple metabolic pathways of metastasis and affect the tumor immune microenvironment.
Authors
- Haoran Huang (ORCID: https://orcid.org/0009-0000-1921-738X)
- Jianlu Zhang (ORCID: https://orcid.org/0000-0002-7913-3003)
- Junchao Guo (ORCID: https://orcid.org/0000-0002-7287-9064)
- Yu Wang (ORCID: https://orcid.org/0000-0002-8833-9564)
- Cong Zhang (ORCID: https://orcid.org/0009-0003-2568-527X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cancer Investigation
- Published
- 2024-11-10
- DOI
- https://doi.org/10.1080/07357907.2024.2424328
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China