LIPOPROTEIN(A) AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASES: THE ROLE AND PROSPECTS FOR APPLYING RESEARCH RESULTS

Background. Lipids and lipoprotein particles contribute to the development of atherosclerosis and determine the risk of cardiovascular diseases. In addition to total cholesterol, low- and high-density lipoproteins (LDL, HDL), other lipid mediators also contribute to cardiovascular risk. Lipoprotein(a) (Lp(a)) is one of them. Current guidelines and consensus statements recommend measuring Lp(a) in all adults at least once in their lifetime. Lp(a) consists of an LDL-like particle in which apoprotein(a) is covalently linked to apoprotein B100 through a single disulfide bond. Lp(a) level is a genetically determined feature. Objective. To analyze the literature on the clinical significance of lipoprotein(a) in the development of cardiovascular diseases. Material and methods. A total of 46 literature sources were analyzed. Conclusions. Given the clear literature data indicating the association of Lp(a) with cardiovascular diseases as independent factors of atherogenesis and thrombogenesis, there is particular interest in studying the role of Lp(a) in the development of cardiovascular events.