PI3K p85α/HIF-1α accelerates the development of pulmonary arterial hypertension by regulating fatty acid uptake and mitophagy
PI3K p85α/HIF-1α induced CD36-mediated fatty acid uptake and Parkin/PINK1-dependent mitophagy to accelerate the progression of experimental PAH.
Authors
- Chenyang Chen (ORCID: https://orcid.org/0000-0002-9002-9207)
- Juan Wen (ORCID: https://orcid.org/0000-0003-1864-8908)
- Xiaogang Li (ORCID: https://orcid.org/0000-0002-7073-7361)
- Zhe Sheng (ORCID: https://orcid.org/0000-0002-6871-1736)
- Sirun Qin
- Yu Cao (ORCID: https://orcid.org/0000-0002-9682-0980)
- Wei Huang (ORCID: https://orcid.org/0000-0002-7279-0932)
- Xiaohua Song (ORCID: https://orcid.org/0000-0001-5667-7094)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s10020-024-00975-9
- Citations
- 13
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China