STUDY OF ANTIBIOTIC RESISTANCE OF LACTIC ACID BACTERIA ISOLATED FROM DAIRY PRODUCTS

In this study, cultures of lactic acid bacteria (3M, 3K, 7K, 9K, 10K and 11K) isolated from mare's milk and koumiss were examined in order to assess their resistance to various antibiotics. Discs impregnated with gentamicin (120 mcg), azithromycin (15 mcg), ceftriaxone (30 mcg), cefuroxime (30 mcg) and chloramphenicol (30 mcg) were used. The data obtained showed that strains 3K, 10K and 11K demonstrated the greatest resistance to gentamicin, similarly, strains 10K and 11K showed high resistance to azithromycin. For ceftriaxone and cefuroxime, strains 11K and 10K demonstrated the greatest resistance. Strains 11K and 10K were the most resistant to chloramphenicol, while strain 3K was the most sensitive. In general, strains 3K and 3M showed the least resistance to most antibiotics, especially ceftriaxone and cefuroxime, which indicates their high sensitivity to these drugs. In contrast, strains 10K and 11K demonstrated the greatest resistance, showing minimal suppression zones for most of the antibiotics studied. The obtained data can be used to develop and optimize probiotic drugs that take into account the resistance of lactic acid bacteria to antibiotics. This will increase the effectiveness of the use of probiotics in various foods and medicines, contributing to the maintenance of healthy intestinal microflora and strengthening the immune system.