p16Ink4a-induced senescence in cultured mast cells as a model for ageing reveals significant morphological and functional changes
The inducible expression of p16<sup>Ink4a</sup> imposes MC senescence, providing a model for tracking the autonomous changes that occur in MCs during ageing. These changes include both morphological and functional alterations. In particular, the increased release of small EVs by senescent MCs suggests an enhanced ability to modulate neighbouring cells.
Authors
- Nicholas Rogers (ORCID: https://orcid.org/0000-0002-0012-9360)
- Ronit Sagi‐Eisenberg (ORCID: https://orcid.org/0000-0002-1990-8831)
- Elisabeth Kleeblatt
- Rajia Bahri (ORCID: https://orcid.org/0000-0001-5969-5941)
- Dan Frenkel (ORCID: https://orcid.org/0000-0002-7494-6857)
- A.K. Langton (ORCID: https://orcid.org/0000-0001-9567-9586)
- Pia Lazki-Hagenbach (ORCID: https://orcid.org/0000-0003-0521-7981)
- Silvia Bulfone‐Paus (ORCID: https://orcid.org/0000-0002-5764-8516)
- Rhonna L. Cohen (ORCID: https://orcid.org/0009-0004-6669-9907)
- Ellon Nabet
Institutions
- Tel Aviv University (IL)
- University of Manchester (GB)
Publication Details
- Journal
- Immunity & Ageing
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s12979-024-00478-5
- Citations
- 5
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Hebrew University of Jerusalem
- Israel Science Foundation
- Tel Aviv University
- Ministry of Science and Technology, Israel