<i>In vitro</i> monitoring of drug resistance emergence during stepwise induction of bedaquiline and clofazimine, alone and in combination: a phenotypic and genotypic analysis
Combined exposure to bedaquiline and clofazimine developed Rv0678 mutation as early as exposure to bedaquiline alone. However, rather than SNPs, deletion and insertion were the dominant mutation types in dual-drug exposure strain.
Authors
- Naihui Chu (ORCID: https://orcid.org/0000-0002-7468-1705)
- Yuanyuan Shang (ORCID: https://orcid.org/0000-0002-3538-7730)
- Suting Chen (ORCID: https://orcid.org/0000-0002-2800-1983)
- Hairong Huang (ORCID: https://orcid.org/0000-0002-4295-4262)
- Fengmin Huo
- Yi Xue (ORCID: https://orcid.org/0009-0007-2328-4586)
- Jifang Zheng
- Liping Zhao (ORCID: https://orcid.org/0000-0003-3100-8454)
- Guanglu Jiang (ORCID: https://orcid.org/0000-0002-6967-552X)
Institutions
- Capital Medical University (CN)
- Beijing Chest Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1093/jac/dkae405
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.78