Therapeutic potential of mackerel-derived peptides and the synthetic tetrapeptide TVGF for sleep disorders in a light-induced anxiety zebrafish model
These findings suggest that MBP1 and TVGF could be promising therapies for light-induced anxiety-like insomnia in humans, offering safer alternatives to current medications. Additionally, the regulation of genes related to circadian rhythm and visual perception may be a key mechanism by which MBP1 and TVGF effectively relieve anxiety-like insomnia.
Authors
- Yang Wang (ORCID: https://orcid.org/0000-0001-9697-5352)
- Changhua Xu
- Shiwei Chai
- Junbao Wang (ORCID: https://orcid.org/0000-0002-7215-8590)
- Yu Li (ORCID: https://orcid.org/0000-0001-7168-3177)
- Haijing Zhang (ORCID: https://orcid.org/0000-0003-2177-6062)
- Xichang Wang (ORCID: https://orcid.org/0000-0002-4115-3367)
- Lei Gu (ORCID: https://orcid.org/0000-0001-9763-3725)
Institutions
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fphar.2024.1475432
- Citations
- 3
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.82
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China