Reduced expression of FOXE1 in differentiated thyroid cancer, the contribution of CPG methylation, and their clinical relevance
<i>FOXE1</i> mRNA was downregulated in DTC compared with non-tumors, followed by high CpGisland methylation. A coupling of low mRNA expression and high methylation status was related to characteristics of aggressiveness in DTC tumors.
Authors
- Ileana Gabriela Sanchez Rubio (ORCID: https://orcid.org/0000-0003-4779-4533)
- Vitória Sousa Frutuoso
- Filipe F. dos Santos (ORCID: https://orcid.org/0000-0003-2335-463X)
- Cláudio Rogério Alves De Lima
- Helton Estrela Ramos (ORCID: https://orcid.org/0000-0002-2900-2099)
- Erika Urbano de Lima
- Rodrigo Esaki Tamura (ORCID: https://orcid.org/0000-0001-7767-0887)
- Janete M. Cerutti (ORCID: https://orcid.org/0000-0003-0156-8274)
- Gustavo Felisola Caso (ORCID: https://orcid.org/0000-0001-9467-1195)
- Igor Campos da Silva (ORCID: https://orcid.org/0000-0002-0556-2972)
- Paloma Ramos de Oliveira
- Anuska Erika Pereira Bezerra
Institutions
- Universidade Federal da Bahia (BR)
- Universidade de São Paulo (BR)
- Universidade de Fortaleza (BR)
- Hospital São Rafael (BR)
- Hospital Sírio-Libanês (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fendo.2024.1454349
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação Amazônia Paraense de Amparo à Pesquisa
- Fundação de Amparo à Pesquisa do Estado da Bahia