Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation
Overall, this preclinical study suggests that the innovative TS dimer disrupters can be optimized by increasing their intracellular accumulation by both inhibiting their outflow and/or enhancing cellular uptake.
Authors
- Davide Illuminati (ORCID: https://orcid.org/0000-0002-0321-1941)
- Renzo Guerrini (ORCID: https://orcid.org/0000-0002-7272-7079)
- Glauco Ponterini (ORCID: https://orcid.org/0000-0002-2115-0775)
- Lorena Losi (ORCID: https://orcid.org/0000-0002-8483-3936)
- Gaetano Marverti (ORCID: https://orcid.org/0000-0002-9074-0795)
- Lorenzo Tagliazucchi (ORCID: https://orcid.org/0000-0002-7244-7106)
- Maria Gaetana Moschella
- Maria Paola Costi (ORCID: https://orcid.org/0000-0002-0443-5402)
- Domenico D’Arca (ORCID: https://orcid.org/0000-0002-7240-6005)
- Alberto Venturelli (ORCID: https://orcid.org/0000-0002-3797-7427)
- Antonio Belardo (ORCID: https://orcid.org/0000-0002-3128-3598)
- Daniele Aiello
- Michele Lamesta
- Giada Mercanile
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Ferrara (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fphar.2024.1477318
- Citations
- 4
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Fondazione Cassa di Risparmio di Modena
- European Commission
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Associazione Italiana per la Ricerca sul Cancro