Morphogen-driven differentiation is precluded by physical confinement in human iPSCs spheroids
Our study combines high-content imaging, synthetic hydrogels, and hiPSCs-derived models of early development to define the drivers that cause changes in the shape and the emergence of germ layers.
Authors
- Yunzhe Guo
- Jeremy Green (ORCID: https://orcid.org/0000-0002-6102-2620)
- Eileen Gentleman (ORCID: https://orcid.org/0000-0003-0447-5137)
- Haneen Alsehli (ORCID: https://orcid.org/0000-0002-6311-5425)
- Errin Roy (ORCID: https://orcid.org/0000-0002-1077-0266)
- Alicja Kuziola
- Thomas Williams (ORCID: https://orcid.org/0000-0002-8724-4678)
- Cecile Ayako Dreiss (ORCID: https://orcid.org/0000-0002-0578-8090)
- Davide Danovi (ORCID: https://orcid.org/0000-0003-4119-5337)
Institutions
- King's College London (GB)
- Oxford Biotherapeutics (United Kingdom) (GB)
- Cell and Gene Therapy Catapult (GB)
- University of Sheffield (GB)
- University of Lausanne (CH)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fbioe.2024.1467412
- Citations
- 1
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.18
Funders
- King's College Hospital NHS Foundation Trust
- National Institute for Health and Care Research
- King's College London
- Rosetrees Trust
- Medical Research Council
- Engineering and Physical Sciences Research Council