The association between serum complement 4 and relapse of primary membranous nephropathy: a multicenter retrospective cohort study
Our study confirms the well-known low Alb and eGFR, PR, and treatment of CNIs at the time of remission as risk factors for PMN relapse, but aPLA2Rab and pathologic features may not predict relapse. In addition, it is the first study to show serum C4 is associated with PMN relapse. We suggest that complement-targeted therapies may be a potential therapy to prevent PMN relapse.
Authors
- W Chen (ORCID: https://orcid.org/0000-0002-0579-6082)
- Fan Zhu (ORCID: https://orcid.org/0000-0002-0750-5496)
- Wei Xiao (ORCID: https://orcid.org/0000-0001-5660-678X)
- Wenyuan Gan (ORCID: https://orcid.org/0000-0001-6636-6011)
- Licong Su (ORCID: https://orcid.org/0000-0002-3085-909X)
- Xingruo Zeng (ORCID: https://orcid.org/0000-0001-9113-9611)
- Xun Fang (ORCID: https://orcid.org/0009-0006-7302-4662)
Institutions
- Nanfang Hospital (CN)
- Central Hospital of Wuhan (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fmed.2024.1451677
- Citations
- 2
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- Health Commission of Hubei Province