Association between proteinuria and mineral metabolism disorders in chronic kidney disease: the Japan chronic kidney disease database extension (J-CKD-DB-Ex)
Chronic kidney disease-mineral and bone disorder (CKD-MBD) are recognized as a systemic disease affecting the prognosis of patients with CKD. Proper management of CKD-MBD is important to improve the prognosis of patients with CKD. Although proteinuria is recognized as a poor prognostic factor in these patients, few reports have examined its association with CKD-MBD. We examined the association between proteinuria and CKD-MBD using data from the Japan Chronic Kidney Disease Database Extension (J-CKD-DB-Ex). Among the patients registered in the J-CKD-DB-Ex, 30,977 with CKD stages G2-G5 who had serum creatinine, albumin, calcium, and phosphate concentrations measured at least once and urinalysis performed were included. The patients were divided into four groups (negative, 1+, 2+, and 3+) according to the degree of proteinuria. The association between proteinuria and CKD-MBD was examined by a logistic regression analysis. In a model adjusted for age, sex, diabetes, and the estimated glomerular filtration rate (eGFR), the odds ratio of the 3 + group compared with the negative group significantly increased to 2.67 (95% confidence interval, 2.29-3.13) for hyperphosphatemia, 2.68 (1.94-3.71) for hypocalcemia, and 1.56 (1.24-1.98) for hypomagnesemia. Proteinuria is associated with hyperphosphatemia, hypocalcemia, and hypomagnesemia in patients with CKD independently of eGFR.
Authors
- Sho Shimamoto (ORCID: https://orcid.org/0000-0002-8252-1525)
- Jun Wada (ORCID: https://orcid.org/0000-0003-1468-5170)
- Eiichiro Kanda (ORCID: https://orcid.org/0000-0003-0676-096X)
- Naoki Kashihara (ORCID: https://orcid.org/0000-0002-9487-984X)
- Kazuhiko Tsuruya (ORCID: https://orcid.org/0000-0002-8390-2928)
- Hajime Nagasu (ORCID: https://orcid.org/0000-0003-2549-4126)
- Masaomi Nangaku (ORCID: https://orcid.org/0000-0001-7401-2934)
- Ichiei Narita (ORCID: https://orcid.org/0000-0001-7692-3096)
- Yuichiro Yano (ORCID: https://orcid.org/0000-0002-2565-7290)
- Hiromi Kataoka (ORCID: https://orcid.org/0000-0001-9491-0723)
- Toshiaki Nakano (ORCID: https://orcid.org/0000-0001-9235-5615)
- Shoichi Maruyama (ORCID: https://orcid.org/0000-0002-8858-632X)
- Shunsuke Yamada (ORCID: https://orcid.org/0000-0003-0359-8987)
- Takashi Yokoo (ORCID: https://orcid.org/0000-0003-1838-7998)
- Hirokazu Okada (ORCID: https://orcid.org/0000-0002-1839-9078)
- Seiji Kishi (ORCID: https://orcid.org/0000-0001-6205-1661)
- Kouichi Tamura (ORCID: https://orcid.org/0000-0002-0660-5372)
- Takashi Wada (ORCID: https://orcid.org/0000-0002-0123-3645)
- Takako Nakahara
- Naoki Nakashima
Institutions
- Kanazawa University (JP)
- Jikei University School of Medicine (JP)
- Kyushu University (JP)
- Okayama University (JP)
- Kawasaki Medical School (JP)
- Juntendo University (JP)
- Nagoya University (JP)
- Kawasaki University of Medical Welfare (JP)
- Nara Medical University (JP)
- Niigata University (JP)
- The University of Tokyo (JP)
- Saitama Medical University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1038/s41598-024-79291-5
- Citations
- 3
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.02