Causal relationship between ferroptosis-related gene HSPA5 and hepatocellular carcinoma: a study based on mendelian randomization and mediation analysis
Elevated HSPA5 expression is significantly associated with HCC development and poor prognosis. HSPA5 may promote HCC progression by regulating the function of Tregs in the tumor microenvironment.
Authors
- Chengyu Mao (ORCID: https://orcid.org/0000-0001-9740-8835)
- Bing Cui (ORCID: https://orcid.org/0000-0001-8374-7801)
- Aqin Chen
- Yuan Xu (ORCID: https://orcid.org/0000-0002-2836-5293)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Chengcheng Xu (ORCID: https://orcid.org/0000-0001-9729-9130)
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
Publication Details
- Journal
- Journal of Zhejiang University (Medical Sciences)
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3724/zdxbyxb-2024-0095
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00