From bioinformatics to anti-inflammation and immune regulation: ACT001 in lipopolysaccharide-induced lung injury
Our study revealed that pyroptosis genes were highly expressed in single-cell and spatial mapping along the first week of ALI occurrence. ACT001 attenuates ALI by reducing the NLRP3-dependent pyroptosis and balancing mitochondrial fission and fusion.
Authors
- Keliang Xie (ORCID: https://orcid.org/0000-0001-6362-6084)
- Yuanlin Wang
- Yan Fan (ORCID: https://orcid.org/0000-0002-7933-5553)
- Weiwei Zhang (ORCID: https://orcid.org/0000-0003-3684-8305)
Institutions
- Nankai University (CN)
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- Allergologia et Immunopathologia
- Published
- 2024-11-01
- DOI
- https://doi.org/10.15586/aei.v52i6.1146
- Citations
- 2
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.48