Dual effects of mefenamic acid on the <i>I</i><sub>Ks</sub> molecular complex
This work highlights the importance of structural motifs at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channels, and their interactions, in determining the nature of drug effects on the I<sub>Ks</sub> channel complex and has important implications for treating patients with specific long QT mutations.
Authors
- Jodene Eldstrom (ORCID: https://orcid.org/0000-0002-7684-175X)
- Magnus Chan
- Harutyun Sahakyan (ORCID: https://orcid.org/0000-0003-3750-8118)
- Vitya Vardanyan (ORCID: https://orcid.org/0000-0001-6731-036X)
- David Fedida (ORCID: https://orcid.org/0000-0001-6797-5185)
- Marc Pourrier
Institutions
- University of British Columbia (CA)
- National Center for Biotechnology Information (US)
- Institute of Molecular Biology (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1111/bph.17389
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Heart and Stroke Foundation of Canada
- Volkswagen Foundation
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada