Uncovering SPP1+ Macrophage, Neutrophils and Their Related Diagnostic Biomarkers in Intracranial Aneurysm and Subarachnoid Hemorrhage
This study highlighted the detrimental role of SPP1<sup>+</sup> Macrophage in IA and SAH using single-cell sequencing and MR analyses. CD36 was identified as a risk factor for IA and SAH and was also an efficient blood biomarker for SAH. In a clinical cohort, neutrophils and related indicators were valuable for the early diagnosis of SAH.
Authors
- Haipeng Jie
- Feng Yan (ORCID: https://orcid.org/0000-0001-8663-6859)
- Xiang Song
- Xinzhao Wang (ORCID: https://orcid.org/0000-0002-1027-6129)
- Changning Fu
- Fan Yang (ORCID: https://orcid.org/0000-0003-0717-5420)
- Boyang Wang (ORCID: https://orcid.org/0000-0002-1487-8557)
- Bo Dong (ORCID: https://orcid.org/0000-0003-1201-8884)
- Jingjing Zhang (ORCID: https://orcid.org/0009-0009-8544-5191)
Institutions
- Shandong University (CN)
- Shandong Tumor Hospital (CN)
- Shandong Provincial Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/jir.s493828
- Citations
- 8
- Primary Topic
- Intracranial Aneurysms: Treatment and Complications
- Type
- article
- Field-Weighted Citation Impact
- 2.95