Characterization of a Highly Virulent Klebsiella michiganensis Strain Isolated from a Preterm Infant with Sepsis
We identified a novel strain of <i>K. michiganensis</i> that exhibits high virulence and leads to severe septicemia phenotypes in preterm infants. Furthermore, comparative genomic analysis of previously reported <i>K. michiganensis</i> strains revealed the existence of three clades. This comprehensive analysis provides novel insights into the genetic relationships and virulence factor profiles of diverse strains of <i>K. michiganensis</i>. In future, it will be necessary to investigate the concept of the high virulence of <i>K. michiganensis</i> to determine the treatment method.
Authors
- Lijuan Ma
- Wanqing Zhuo (ORCID: https://orcid.org/0000-0001-5272-7242)
- Peipei Zhang (ORCID: https://orcid.org/0000-0001-9070-9328)
- Di Zhang (ORCID: https://orcid.org/0000-0001-6565-0088)
- Yue Du (ORCID: https://orcid.org/0000-0002-3865-0805)
- Yajuan Wang (ORCID: https://orcid.org/0000-0002-3284-9012)
- Panpan Xu (ORCID: https://orcid.org/0009-0009-2064-7200)
- Lin Zhou (ORCID: https://orcid.org/0000-0002-1958-5286)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Capital Institute of Pediatrics (CN)
- Children's Hospital of Capital Institute of Pediatrics (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/idr.s481750
- Citations
- 4
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 2.47
Funders
- Beijing Municipal Health Commission