A STUDY OF ASSOCIATION OF FIRST TRIMESTER SERUM URIC ACID LEVELS WITH DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS

Objectives: GDM is a major pregnancy complication that can cause maternal and foetal morbidity and mortality . A substantial amount of research suggests that uric acid may be a major risk factor for the development of diabetes in women.The purpose of this research was to determine whether early pregnancy maternal blood uric acid levels and the onset of gestational diabetes mellitus are interrelated.Methods:The prospective observational study was conducted in Government general hospital, Kurnool from November 2023 to May 2024. Pregnant women of gestational age up to 13 weeks who visited the OBG outpatient department for regular antenatal check-ups during this time period were enrolled in the study with prior consent.Result:In our study,among the 360 pregnant women,43 (12%) developed GDM. Of these Women with GDM 34 (79.07%) had uric acid levels above 3.5 mg/dl and 9 women (20.93%) with GDM had uric acid levels below 3.5 mg/dl. In present study, the serum Uric acid levels with the criteria of >3.5mg/dl , demonstrated that sensitivity of 80.95% and specificity of 97.16%.Conclusion:There is a strong association between the onset of GDM and an elevated serum uric acid level during the first trimester.A 3.5 mg/dl cut-off level appears to have good sensitivity and specificity.