INTEGRATIVE INDICATORS OF ENDOGENOUS INTOXICATION, INFLAMMATORY ACTIVITY, AND SPECIFIC REACTIVITY IN PATIENTS WITH COVID-19

The aim of the study is to identify changes in blood laboratory parameters, integrative indicators of endogenous intoxication, inflammation, and specific reactivity in patients with coronavirus disease. Patients and methods. The study included 77 patients with COVID-19, taking into account the inclusion and exclusion criteria. The comparison group consisted of 68 practically healthy people of the corresponding age. Laboratory blood tests were performed, on the basis of which integrative indicators of endogenous intoxication, inflammation and specific reactivity were calculated. Results. The data of the general blood test showed no significant differences between the patients of the groups, the indicators remained within acceptable limits. A slight inflammatory reaction in patients with COVID-19, especially in the period from 3 to 6 months, is confirmed by an increase in the level of endogenous intoxication (LII, LSI, NLRI, HII) in the group of patients compared to healthy individuals. During the same period, there are signs of activation of the cellular immune system in response to the presence of latent bacterial infection or endogenous intoxication, which is confirmed by a decrease in inflammation activity (LGI, LESRI, CI). Reduced indices of nonspecific reactivity (RC, ILYM, AI) confirmed the activation of the cellular immune system, given the decrease in the number of lymphocytes relative to granulocytes. Changes in integrative indices did not depend on the presence of Long-COVID symptoms. In the period from 12 months after the coronavirus disease, the development of autoimmune processes is possible, since there was a tendency to decrease the indices of endogenous intoxication (NLRI, LSI) simultaneously with an increase in the indices of inflammatory activity (LGI, LESRI, TI) and indices of nonspecific reactivity (RC, Ilymph, AI).