Hematological Changes in Pre and Post Dialysis in Patients Undergoing Hemodialysis: A Comparative Study at Zawia Hospital

Chronic kidney disease (CKD) is a common condition that affects millions of people worldwide, and is responsible for high morbidity and mortality rates. The progression of CKD is associated with several serious complications and changes in blood composition. Thus, patients with CKD require dialysis to manage the disease. This study assessed the impact of haemodialysis on changes in pre and post haematological parameters in CKD patients. A cross-sectional study was carried out at Al-Zawiya Dialysis Hospital in Libya. Sixty patients with CKD were regularly undergoing haemodialysis three times a week. Data were analysed by SPSS 24.0 version. The study shows significant differences in blood parameters before-dialysis and after-dialysis levels. The mean WBC 6.22 × 10^3/µL to 6.03 × 10^3/µL, (p = 0.0045), the mean RBC 3.56 × 10^6/µL to 3.66 × 10^6/µL, (p = 0.001), the mean HCT in pre and post-haemodialysis was 32.01% to 32.71% (p = 0.018), the mean Haemoglobin 10.11 g/Dl in pre - dialysis to 10.32 g/dL post - dialysis (p = 0.027 ), the mean MCV 90.24 fL to 89.69 fL ,(p < 0.0001), the mean MCH in pre and MCH in pre and post-haemodialysis post- haemodialysis was 28.58 pg to 28.5 pg,(p < 0.0001), the mean MCHC in pre and post-haemodialysis (p = 0.003), and PLT was 241.08 × 10^3/µL to 240.46 × 10^3/µL in pre and post-haemodialysis, (p = 0.002). The different degrees of abnormality in haematological parameters in patients with renal disease under haemodialysis need careful evaluation and management. Routine assessment of these parameters is important in treatment and can help lower morbidity and mortality rates among these patients