Targeting endoplasmic reticulum stress‐induced lymphatic dysfunction for mitigating bisphosphonate‐related osteonecrosis
Bisphosphonate-induced lymphatic drainage impairment exacerbates bone necrosis. Zoledronate acid triggers endoplasmic reticulum stress and apoptosis in lymphatic endothelial cells via the NAD+/SIRT6/XBP1s pathway. Novel nanoparticle-loaded Zoledronate acid and rapamycin enhances autophagy, restores lymphatic function, and mitigates bisphosphonates-related osteonecrosis of the jaw progression.
Authors
- Hongbing Jiang (ORCID: https://orcid.org/0000-0002-3748-0381)
- Rongyao Xu (ORCID: https://orcid.org/0000-0002-1508-437X)
- Songsong Guo (ORCID: https://orcid.org/0000-0001-7878-6128)
- Ziyue Qin (ORCID: https://orcid.org/0000-0002-1520-8272)
- Yu Fu (ORCID: https://orcid.org/0000-0002-6225-0270)
- Ping Zhang (ORCID: https://orcid.org/0000-0001-6374-673X)
- Zesheng Song
- Hanyu Xie (ORCID: https://orcid.org/0009-0000-2595-7317)
- Pengcheng Su
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1002/ctm2.70082
- Citations
- 7
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- National Natural Science Foundation of China