Pim1 inactivating induces RUNX3 upregulation that improves/alleviates airway inflammation and mucus hypersecretion in vitro and in vivo
Our results suggest that Pim1 inactivation can ameliorate airway inflammation and mucus hypersecretion through upregulation of Runx3 and the effect could be mediated through modulation of the PI3K/AKT/NF-κB pathway.
Authors
- Lanzhi Zhou
- Zhen Guo (ORCID: https://orcid.org/0000-0002-1541-421X)
- Haiyan Li (ORCID: https://orcid.org/0000-0003-0556-7340)
- Yanni Fang
- Juan Zhang (ORCID: https://orcid.org/0000-0003-1067-7878)
- Jumei Hao (ORCID: https://orcid.org/0000-0001-9941-4438)
Institutions
- Yantaishan Hospital (CN)
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/bmjresp-2023-002066
- Citations
- 3
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.27