Clinical significance of post-COVID-19 in patients with hypertension, taking into account the polymorphism of genes encoding components of the renin-angiotensin system

To date, there has been no consensus on the impact of polymorphism of components of the renin-angiotensin-aldosterone system (RAAS) on the course of a new coronavirus infection or a possible role in post-COVID syndrome. The objective is to study the significance of COVID-19 and gene polymorphism encoding components of renin angiotensin system in patients with hypertension. Materials and methods: A clinical examination was conducted on 116 stage 2 hypertensive patients with uncontrolled hypertension. Of these, 96 underwent mild or moderate COVID-19, 51 before 12 weeks and 45 after 12. Results. Patients in the ongoing symptomatic phase of COVID- 19 had higher systolic blood pressure than those with post COVID syndrome (p1-2 = 0.03659, p1-3 ≤ 0,00001).The association of polymorphisms of genes AGT:704T>C, AGT521C>T, AGTR1:1166A>C, AGTR2:1675G>A, CYP1IB2:-344C>T with gender, BMI and COVID-19 transmission has not been identified. In the symptomatic phase of COVID-19, carriage of the TT genotype for the AGT704 gene was less frequent (p=0.005) compared to the control group. Conclusions. The effect of COVID on an increase in blood pressure in stage 2 hypertensive patients was determined. An association between blood pressure instability and BMI after COVID was established. During the symptomatic COVID phase, there was an association between increased blood pressure and the C allele of AGT gene polymorphisms (T704).