The Role of FLT3-ITD Mutation, PI3K/AKT Pathway, and Leukemia Stem Cells in D3A7 Induction therapy – the Outcomes of Adult Indonesian Patients with Acute Myeloid Leukemia
This study presents the important role of FLT3-ITD mutation via its downstream signaling (PI3K/AKT) in the outcome of D3A7 induction therapy. The FLT3-ITD mutation plays an important role in the 12-month survival of AML patients after D3A7 therapy. However, the outcome of D3A7 therapy and FLT3-ITD mutation were not associated with leukemia stem cells.
Authors
- Melva Louisa (ORCID: https://orcid.org/0000-0002-9451-0380)
- Elly Yanah Arwanih
- Ikhwan Rinaldi (ORCID: https://orcid.org/0000-0002-6872-8802)
- Septelia Inawati Wanandi (ORCID: https://orcid.org/0000-0002-7963-8853)
Institutions
- University of Indonesia (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
Publication Details
- Journal
- Acta Medica Academica
- Published
- 2024-08-31
- DOI
- https://doi.org/10.5644/ama2006-124.453
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91