Causal Pathways Between Breast Cancer and Cardiovascular Disease Through Mediator Factors: A Two-Step Mendelian Randomization Analysis
This study elucidates the potential causal impact of ER+ BC on subsequent risk of CVD, including CHD, HHD, IHD, and HF. We also outline the metabolic mediator HDL-C as a priority target for preventive measures to reduce excessive risk of CVD among patients diagnosed with ER+BC.
Authors
- Weilin Lu (ORCID: https://orcid.org/0009-0007-5616-621X)
- Yinxing Zhu (ORCID: https://orcid.org/0000-0002-7417-9109)
- Yan Ding (ORCID: https://orcid.org/0000-0002-4269-9476)
- Zhipeng Liu (ORCID: https://orcid.org/0009-0001-5967-6721)
- Kaiming Li (ORCID: https://orcid.org/0000-0001-5545-3419)
- Xiaolin Li (ORCID: https://orcid.org/0000-0002-7510-9735)
- Jinyu Li (ORCID: https://orcid.org/0000-0002-3489-065X)
- Haisi Wu
- Huae Xu (ORCID: https://orcid.org/0000-0001-9124-303X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- International Journal of Women s Health
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/ijwh.s483139
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Bethune Charitable Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Nanjing Medical University