<scp>CaMKII</scp> Exacerbates Doxorubicin‐Induced Cardiotoxicity by Promoting Ubiquitination Through <scp>USP10</scp> Inhibition
Our findings revealed that DOX-induced myocardial apoptosis and activated CaMKII through cellular and animal levels, while providing a novel probe into the mechanism of CaMKII action: promoting ubiquitination by inhibiting USP10 aggravated apoptosis.
Authors
- Nisha Wang
- Zhenyi Wang (ORCID: https://orcid.org/0000-0002-4146-9433)
- Jian Yang (ORCID: https://orcid.org/0000-0002-1869-7913)
- Lifang Yang (ORCID: https://orcid.org/0000-0002-4004-9883)
- Yitong Yang (ORCID: https://orcid.org/0009-0007-5836-3882)
Institutions
- Affiliated Hospital of Shaanxi University of Chinese Medicine (CN)
- Xi’an Children’s Hospital (CN)
- Xijing Hospital (CN)
- Shaanxi University of Chinese Medicine (CN)
- Xi'an Jiaotong University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1002/cam4.70286
- Citations
- 4
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China