<scp>PTP1B</scp> Modulates Carotid Plaque Vulnerability in Atherosclerosis Through Rab5‐<scp>PDGFRβ</scp>‐Mediated Endocytosis Disruption and Apoptosis
Our results illustrate that PTP1B induces disruption in endocytosis and apoptosis of VSMCs through the Rab5-PDGFRβ pathway, suggesting a potential association with the heightened vulnerability of carotid plaques.
Authors
- Ge Yang (ORCID: https://orcid.org/0000-0001-6176-3130)
- Liqun Jiao (ORCID: https://orcid.org/0000-0003-4982-6295)
- Zixuan Xing (ORCID: https://orcid.org/0000-0001-7935-2575)
- Yixin Sun (ORCID: https://orcid.org/0000-0001-9090-4350)
- Xiaohong Zhang (ORCID: https://orcid.org/0000-0002-6732-2499)
- Wenjing Li (ORCID: https://orcid.org/0000-0003-1154-2895)
- Tao Wang (ORCID: https://orcid.org/0000-0003-1225-0173)
- Jiayao Li (ORCID: https://orcid.org/0000-0002-3814-2691)
- Ran Xu (ORCID: https://orcid.org/0000-0003-1387-6696)
- X. R. Lyu (ORCID: https://orcid.org/0000-0001-5689-9578)
- Shengyan Cui
Institutions
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Shandong Institute of Automation (CN)
- Beijing Academy of Artificial Intelligence (CN)
- Institute of Automation (CN)
- Peking University First Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1111/cns.70071
- Citations
- 4
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Beijing Municipal Natural Science Foundation
- Beijing Nova Program