Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO/m6A-P53 pathway
These findings suggest that HYF holds promise as a potential treatment for POI and provide a more comprehensive understanding of the mechanism by which HYF operates, specifically its ability to prevent the BCL-2 mitochondrial apoptosis pathway mediated by P53 in ovarian granulosa cells of POI rats by regulating FTO/m6A-Tp53.
Authors
- Jian Liu (ORCID: https://orcid.org/0000-0003-3101-7553)
- Yang Li (ORCID: https://orcid.org/0000-0002-8200-1546)
- Lingdi Wang
- Hongyan Yang (ORCID: https://orcid.org/0000-0003-1916-0955)
- Guangning Nie
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.3389/fphar.2024.1491546
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China