Timely escalation to second-line therapies after failure of methotrexate in patients with early rheumatoid arthritis does not reduce the risk of becoming difficult-to-treat
Early implementation of treatment after failure of treat-to-target with MTX may not prevent the development of D2T in RA. Patients showing early refractoriness to conventional drugs and those lacking autoantibodies are at higher risk of multiple treatment failures.
Authors
- Emanuele Bozzalla Cassione (ORCID: https://orcid.org/0000-0001-6578-6938)
- Carlomaurizio Montecucco (ORCID: https://orcid.org/0000-0001-8263-3925)
- Ludovico De Stefano (ORCID: https://orcid.org/0000-0002-2312-2161)
- Garifallia Sakellariou (ORCID: https://orcid.org/0000-0002-1849-5123)
- Francesca Cuzzocrea (ORCID: https://orcid.org/0000-0002-3527-2386)
- Antonio Manzo
- Serena Bugatti (ORCID: https://orcid.org/0000-0002-5396-7077)
- Bernardo D’Onofrio (ORCID: https://orcid.org/0000-0003-4122-5057)
- Valentina Morandi
Institutions
- University of Pavia (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- University Hospital Foundation (CA)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-11-08
- DOI
- https://doi.org/10.1186/s13075-024-03431-5
- Citations
- 2
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Fondazione IRCCS Policlinico San Matteo