Relationship between lactate and thiamine-responsive disorders in hospitalised infants and children in Lao PDR: secondary analysis of a prospective cohort study
In children with signs/symptoms of thiamine deficiency, hyperlactataemia is associated with a favourable clinical response to thiamine, biochemical thiamine deficiency, and increased odds of mortality. Lactate may be useful in identifying children who might benefit from therapeutic thiamine.
Authors
- Kerry S. Jones (ORCID: https://orcid.org/0000-0002-7380-9797)
- Dalaphone Sitthideth
- Philip R. Fischer (ORCID: https://orcid.org/0000-0003-0876-8789)
- Kristin Cardiel Nunez (ORCID: https://orcid.org/0000-0002-8091-9273)
- Charles D. Arnold (ORCID: https://orcid.org/0000-0001-6510-3172)
- Sengchanh Kounnavong (ORCID: https://orcid.org/0000-0001-5766-5941)
- Indi Trehan (ORCID: https://orcid.org/0000-0002-3364-6858)
- Sonja Y. Hess (ORCID: https://orcid.org/0000-0002-4661-277X)
- Taryn J. Smith (ORCID: https://orcid.org/0000-0001-9543-6461)
- Laurent Hiffler (ORCID: https://orcid.org/0000-0001-5197-230X)
Institutions
- Children's Hospital of Philadelphia (US)
- Khalifa University of Science and Technology (AE)
- University of Washington (US)
- University of Cambridge (GB)
- National Institute of Public Health (LA)
- Mayo Clinic in Florida (US)
- MRC Epidemiology Unit (GB)
- University of California, Davis (US)
Publication Details
- Journal
- Paediatrics and International Child Health
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1080/20469047.2024.2421624
- Citations
- 1
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- Bill and Melinda Gates Foundation
- National Institute for Health and Care Research
- Department of Health and Social Care
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre
- National Center for Advancing Translational Sciences