Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency
Linezolid-treated patients with HAP and renal insufficiency had higher bacterial eradication rates, supratherapeutic exposure and adverse reactions than teicoplanin-treated patients. Linezolid dose reduction in patients with renal insufficiency improved the probability of achieving optimal exposure.
Authors
- Chenqi Zhu (ORCID: https://orcid.org/0000-0002-4524-6827)
- Jian Lü (ORCID: https://orcid.org/0000-0002-9635-7033)
- Zhiwei Zhuang
- Xianglong Chen
- Lu Shi (ORCID: https://orcid.org/0000-0001-6092-780X)
- Yunlong Yuan
- Lian Tang (ORCID: https://orcid.org/0000-0002-8553-2238)
- Yanxia Yu (ORCID: https://orcid.org/0009-0000-9752-2806)
- Jinhui Xu
- Lufen Duan
- Jingjing Li (ORCID: https://orcid.org/0009-0001-9385-0535)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5975-9781)
Institutions
- Suzhou Municipal Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/dddt.s474470
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Pharmaceutical Association
- Nanjing Medical University
- Science and Technology Program of Suzhou