Enantioconvergent Negishi Cross‐Couplings of Racemic Secondary Organozinc Reagents to Access Privileged Scaffolds: A Combined Experimental and Theoretical Study
An enantioconvergent palladium-catalyzed Negishi cross-coupling with racemic secondary organozinc reagents has been developed, enabling access to enantioenriched 1,1-diarylalkane motifs in high yields and enantioselectivities. Computational data indicates that the racemization of organozinc compounds most likely occurs through a bridged bimolecular mechanism.
Authors
- Leticia González (ORCID: https://orcid.org/0000-0001-5112-794X)
- Alexander Preinfalk (ORCID: https://orcid.org/0000-0001-6561-348X)
- Rik Oost
- Boris Maryasin (ORCID: https://orcid.org/0000-0001-7943-7333)
- Maximilian F. S. J. Menger (ORCID: https://orcid.org/0000-0003-1442-9601)
- Samuel Senoner
- Marwan Simaan (ORCID: https://orcid.org/0000-0003-2598-7406)
- Sébastien Lemouzy (ORCID: https://orcid.org/0000-0002-4581-9453)
- Saad Shaaban (ORCID: https://orcid.org/0000-0002-2578-6260)
- Nuno Maulide (ORCID: https://orcid.org/0000-0003-3643-0718)
Institutions
- University of Vienna (AT)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1002/anie.202414868
- Citations
- 4
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- Österreichischen Akademie der Wissenschaften