Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression
SHARPIN was identified as an upregulated anti-apoptotic protein in CRC, and matrine exhibited anticancer effects by downregulating its expression. Thus, matrine appears to be a promising drug for CRC.
Authors
- Dongyan Zhao (ORCID: https://orcid.org/0000-0002-2080-8416)
- Ge-Yu-Jia Zhou
- Shukun Yao (ORCID: https://orcid.org/0000-0002-8512-2589)
- Xizhen Sun (ORCID: https://orcid.org/0000-0001-5241-342X)
- Tengfei Yin
- Qianqian Wang (ORCID: https://orcid.org/0000-0003-3514-455X)
- Yuan-Chen Zhou
- Lei Zhou (ORCID: https://orcid.org/0000-0002-2303-5674)
- Chang Tan
Institutions
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
- Beijing Jishuitan Hospital (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.4251/wjgo.v16.i12.4700
- Citations
- 6
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.40