Anti‐retinal Autoantibodies in Hydroxychloroquine Eye Toxicity
Anti-retinal AAbs were more common in patients with SLE with HCQ retinal toxicity. When controlling for risk factors associated with HCQ toxicity, anti-arrestin AAbs were associated with increased odds for the development of eye toxicity, suggesting a potential role for anti-retinal AAbs as a biomarker of HCQ eye toxicity.
Authors
- Grażyna Adamus (ORCID: https://orcid.org/0000-0001-5439-7400)
- Maureen McMahon (ORCID: https://orcid.org/0000-0002-2910-7640)
- Michael B. Gorin (ORCID: https://orcid.org/0000-0001-9498-7982)
- Jennifer M. Grossman (ORCID: https://orcid.org/0000-0002-6403-4424)
- Samuel D. Good (ORCID: https://orcid.org/0000-0003-2153-3714)
- AM Kamrul Hasan
- Isao Matsuura (ORCID: https://orcid.org/0000-0001-9614-9982)
- Jordan Jacquez
- Brian J. Skaggs (ORCID: https://orcid.org/0000-0002-9215-0596)
Institutions
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- Doheny Eye Institute (US)
- Asahi General Hospital (JP)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1002/acr2.11743
- Citations
- 1
- Primary Topic
- Drug-Induced Ocular Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- U.S. Department of Defense
- Research to Prevent Blindness