Activation of MEK‐ERK‐c‐MYC signaling pathway promotes splenic M2-like macrophage polarization to inhibit PHcH-liver cirrhosis
Activation of MEK-ERK-c-MYC signaling pathway promotes splenic M2-like macrophage polarization to inhibit PHcH-liver cirrhosis. Therefore, the induction of macrophage depolarization might represent a new therapeutic approach in the cure of PH hypersplenism, making c-Myc a potential candidate for macrophage polarization therapy.
Authors
- Wang Gui-hu
- Rui Zhou (ORCID: https://orcid.org/0000-0002-1818-7710)
- Zongfang Li
- Chongyu Zhang (ORCID: https://orcid.org/0000-0002-7302-595X)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-6585-2808)
- Chen Zhang (ORCID: https://orcid.org/0000-0002-0680-5032)
- Dong Wei (ORCID: https://orcid.org/0000-0002-6342-4658)
- Xi Liu (ORCID: https://orcid.org/0000-0002-8654-0774)
- Hailong Zhang (ORCID: https://orcid.org/0000-0002-1806-4454)
- Jin Sun (ORCID: https://orcid.org/0000-0003-4332-2870)
- Song Ren
- Jiang An
- Zhu Mengchen
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-08
- DOI
- https://doi.org/10.3389/fimmu.2024.1417521
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- University of Pittsburgh
- National Natural Science Foundation of China
- Medical Center, University of Pittsburgh
- Bijzonder Onderzoeksfonds UGent